The Eno Indians, a tribe associated with the Adshusheer and Shakori in 17th-century North Carolina, were likely of Siouan linguistic stock, although their distinct physical traits and habits led to some doubts regarding their classification. First mentioned in 1654, the Eno, along with the Shakori, lived near present-day Durham and Hillsboro, North Carolina, with their primary village, Adshusheer, located along the Eno River. By 1701, the Eno, Shakori, and Adshusheer had formed a confederation, with the Shakori emerging as the dominant group. Over time, the Eno, like other small tribes, faced pressure from European colonization and warfare, eventually migrating southward and becoming absorbed into larger groups like the Catawba or Saponi by the early 18th century. Their unique customs, including round homes made of interwoven branches plastered with mud, and their distinctive cultural practices set them apart from neighboring tribes. The Eno name endures in local geographic features like the Eno River in North Carolina and possibly the Enoree River in South Carolina.