During the 1500s and early 1600s, when Spanish explorers were first making contact with the indigenous inhabitants of the Florida, they made contact with a powerful nation on the southwest coast between Charlotte Harbor and Cape Sable. 1MacMahon, Darcie A. and William H. Marquardt. (2004). The Calusa and Their Legacy: South Florida People and Their Environments. University Press of Florida; pp. 1-2. The first contact was made in 1513 by Juan Ponce de Leon, when he landed at the mouth of the Caloosahatchee River in southwest Florida. His landing boats were attacked by Calusa war canoes, lined with round shields.